3601-66-9

24424-99-5

2835-06-5

2900-27-8

General procedure for the synthesis of BOC-L-phenylglycine from di-tert-butyl dicarbonate and 2-amino-2-phenylacetic acid: DL-2-phenylglycine (5.0 g, 33 mmol) was dissolved in 1 N NaOH solution (132 mL). Subsequently, di-tert-butyl dicarbonate (19.0 mL, 82.7 mmol) was added and the reaction mixture was stirred at room temperature until the reaction was complete. N-tert-butoxycarbonyl-DL-phenylglycine was isolated as a white solid (7.61 g, 92% yield) by appropriate post-processing steps.