35431-26-6

142677-24-5

35431-26-6

The general procedure for the synthesis of 5-hydroxy-2-methoxybenzaldehyde from 2-methoxy-5-(methoxymethoxy)benzaldehyde was as follows: to a solution of 2-methoxy-5-(methoxymethoxy)benzaldehyde (33.5 g, 0.17 mol, 1 eq.) in tetrahydrofuran (THF, 150 mL) was added 3N hydrochloric acid (HCl, 250 mL, 4.4 eq.). The reaction mixture was stirred at 50 °C for 1 h, subsequently cooled to room temperature and diluted with deionized water (500 mL). The mixture was neutralized to pH 7-8 with solid potassium carbonate (K2CO3). the light yellow solid product was collected by filtration, washed with deionized water and dried to afford 5-hydroxy-2-methoxybenzaldehyde (17.9 g, 74.6% yield) as a light yellow solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, DMSO-d6): δ= 10.31 (s, 1H), 8.03 (s, 1H), 6.89 (s, 1H), 3.80 (s, 3H). Low resolution mass spectrometry (LRMS) showed the molecular ion peak (M+H+) m/z 154.0.