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N-MethyltrifluoroMethanesulfonaMide is a dioxane that is used as an intermediate for the production of other chemicals. It has been shown to form bifurcated intramolecular hydrogen bonds and isomers with stereospecificity. The molecule can be prepared by reacting methylamine with chlorotrifluoromethane followed by hydrolysis of the resulting N-MethyltrifluoroMethanesulfonaMide chloride. This compound is soluble in both water and organic solvents, such as methanol, ethanol, acetone, and chloroform. It has been found to have a high affinity for amines and amides and will form hydrogen bonds with these compounds.

N,N-Diethyl-1,1,1-trifluoromethanesulfonamide is used in the preparation of hexaalkylguanidinium trifluoromethanesulfonates from tetraalkylureas, triflic anhydride and secondary amines and their properties as ionic liquids.