342808-40-6

3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone is an analog of curcumin that acts as a kinase inhibitor which mediates anticancer properties.

EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcuminwith 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilizationin contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK)resulting in suppression in NFKB activity.''EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcuminwith 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1α posttranscriptional activity and induces microtubule stabilizationin contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell

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