331248-11-4

Name	LG 101506
CAS	331248-11-4
Molecular Formula	C25H34F2O3
MDL Number	MFCD19690911
Molecular Weight	420.53
MOL File	331248-11-4.mol

Synonyms

LG 101506 (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid

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Chemical Properties

Boiling point	522.0±50.0 °C(Predicted)
density	1.052±0.06 g/cm3(Predicted)
solubility	DMSO:42.05(Max Conc. mg/mL);100.0(Max Conc. mM) Ethanol:21.03(Max Conc. mg/mL);50.0(Max Conc. mM)
pka	4.73±0.33(Predicted)

Hazard Information

Uses

LG 101506 is a selective RXR modulator. It has anti-carcinogenic properties. This was demonstrated in a biological study where it was used suppress lung carcinogenesis in mice.

in vivo

LG101506 (10 mg/kg; in diet for 16 weeks) suppresses lung carcinogenesis in A/J mice^[2].

Animal Model:	A/J mice, lung carcinogenesis model^[2]
Dosage:	40 mg/kg diet or approximately 10 mg/kg body weight
Administration:	Oral, for 16 weeks
Result:	Reduced the number of lung tumors, the average tumor burden, the size and histopathology of lung tumors.

Animal Model:

Male ICR mice^[1]

Dosage:

30 mg/kg

Administration:

Oral (Pharmacokinetic Analysis)

Result:

In vivo evaluation of oral exposure of LG101506^[1]

Compd	Dose (mg/kg)	Oral AUC_{(0-6 h)} (μg?h/mL)	T_max (h)	C_max (μg?h/mL)
LG101506	30	2.09±0.45	1	1.2±0.28

Data collected in male ICR mouse using a dose formulation of the free acid in CMC/SLS/Povidone (30 mg/kg). Timepoints: 1, 3, 8 h (serial sacrifice, n=3/time point).

storage

Store at +4°C

Supplier

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Telephone13761987713; 13761987713

Websitehttps://www.sunwaypharm.cn

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

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