ChemicalBook CAS DataBase List 33100-27-5

33100-27-5

Name	15-Crown-5
CAS	33100-27-5
EINECS(EC#)	251-379-6
Molecular Formula	C10H20O5
MDL Number	MFCD00005110
Molecular Weight	220.26
MOL File	33100-27-5.mol

Chemical Properties

Appearance	colourless liquid
Melting point	-20°C(lit.)
Boiling point	93-96 °C/0.05 mmHg (lit.)
density	1.113 g/mL at 20 °C(lit.)
vapor pressure	0.5-0.82Pa at 20-25℃
refractive index	n20/D 1.465(lit.)
Fp	>230 °F
storage temp.	room temp
solubility	Miscible with organic solvents.
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.109
Stability:	Stable. Incompatible with oxidizing agents, strong acids. Avoid exposure to water or moist air.
Water Solubility	MISCIBLE
Sensitive	Hygroscopic
BRN	1618144
LogP	-0.9 at 20℃ and pH7.7
Surface tension	68.5mN/m at 1g/L and 20℃
CAS DataBase Reference	33100-27-5(CAS DataBase Reference)
NIST Chemistry Reference	15-Crown-5(33100-27-5)
EPA Substance Registry System	33100-27-5(EPA Substance)

Safety Data

Hazard Codes	Xn,Xi
Risk Statements	R22:Harmful if swallowed. R36/38:Irritating to eyes and skin . R36:Irritating to the eyes. R20/22:Harmful by inhalation and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S39:Wear eye/face protection . S36:Wear suitable protective clothing . less more
RIDADR	2810
WGK Germany	3
RTECS	SB0200000
F	10-21
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329995
Toxicity	LD50 orl-rat: 1410 mg/kg DCTODJ 1,339,78 less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

colourless liquid

Uses

15-Crown-5 is used as an efficient phase transfer catalyst and as a complexing agent. It is used to isolate oxonium ion (H7O3)+ salts especially from a solution of tetrchloroauric acid. It catalyzes the O-alkylation of the sodium salts of carboxylic acids in the penicillin and cephalosporin series, thereby facilitating esterification reaction without usage of acid. It is also used to facilitate the Williamson synthesis of ethers with hindered alcohols and sodium hydride. It is used with lithium aluminum hydride, for performing reduction reactions in hydrocarbon solvents. Further, it is involved in the Horner-Wadsworth-Emmons reaction to prepare stilbenes from aldehydes.

Definition

ChEBI: A saturated organic heteromonocyclic parent that is cyclopentadecane in which the carbon atoms at positions 1, 4, 7, 10 and 13 have been replaced by oxygen atoms to give a crown ether.

General Description

15-Crown-5 is a crown ether generally used as a ligand in coordination chemistry because of its strong chelating property with certain alkali cations to form complexes. Some derivatives of 15-crown-5 are used as sensors and probes in different physical-chemical processes, phase-transfer reactions, and selective capture of ions for separation and transport.

Safety Profile

Moderately toxic by ingestion, skin contact, and intraperitoneal routes. A skin and eye . When heated to decomposition it emits acrid smoke and irritating fumes

Purification Methods

Dry it over 3A molecular sieves and distil it in a high vacuum. [Beilstein 19/12 V 252.]

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

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33100-27-5

Chemical Properties

Safety Data

Raw materials And Preparation Products

Preparation Products

Hazard Information

Chemical Properties

Uses

Definition

General Description

Safety Profile

Purification Methods

Material Safety Data Sheet(MSDS)

Questions And Answer

use

Introduction

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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