Description
Epitalon(307297-40-1) is a synthetic tetrapeptide with anti-aging properties. This peptide was originally discovered by the Russian scientist Professor Vladimir Khavinson. Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates. Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice. It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice. Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.
Uses
Epitalon is an anti-aging agent and a telomerase activator, with an inhibitory effect of the on the development of spontaneous tumors in mice, as well as geroprotective actions and intranasal administration increases neuronal activity, also can be used for cancer, old age and Retinitis Pigmentosa.
benefits
Epitalon has been called the "fountain of youth" peptide because of its rejuvenating effects. As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:
May increase human lifespan by lengthening telomeres in human cells
Prevent the effects of Free radicals
Promotes Deeper Sleep
Delay and prevention of age-related diseases such as cancer, heart disease, and dementia
Can act as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function.
Improvement of skin health and appearance
Healing of injured and deteriorating muscle cells
Has been shown to Restore and normalize melatonin levels in older people who have lost some pineal function due to aging
May increases resistance to emotional stress
Mode of action
Epitalon works in the pineal gland of the brain. Its primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA, so the body can grow new cells and rejuvenate old ones. It has shown a 33% increase in telomere length in somatic cells. It has many documented effects on general aging and impacts on the circadian rhythm. It promotes a natural cycle and healthy sleep cycles, it also makes sure that cortisol and other stress hormones are not elevated throughout the day, which can lead to excess abdominal weight gain. It helps regulate levels of melatonin and cortisol. It helps make sure cortisol is elevated in the morning and melatonin is elevated in the evening.?
Preparation and handling
Epitalon (acetate) is supplied as a solid. A stock solution may be made by dissolving the epitalon (acetate) in the solvent of choice. Epitalon (acetate) is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of epitalon (acetate) in these solvents is approximately 3 and 1 mg/ml, respectively.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of epitalon (acetate) can be prepared by directly dissolving the solid in aqueous buffers. The solubility of epitalon (acetate) in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.
