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V-06-018 is a quorum sensing modulator that acts as a LasR antagonist.

V-06-018 is a potent LasR antagonist with an IC50 value of 5.2 μM. V-06-018 can be used as chemical probes of quorum sensing (QS) in Pseudomonas aeruginosa[1].

[1] Manson DE, et al. Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values. ACS Infect Dis. 2020 Apr 10;6(4):649-661. DOI:10.1021/acsinfecdis.9b00518