2883495-39-2

Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis[1].

CA Ⅸ: 0.33 μM (IC₅₀); CA XII: 0.68 μM (IC₅₀); NPP1: 1.13 μM (IC₅₀); NPP2: 1.07 μM (IC₅₀); NPP3: 0.74 μM (IC₅₀)

[1] Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.