KUM 32 is a potent antagonist of epinephrine-induced platelet aggregation. KUM 32 is an adenylate cyclase activity inhibitor. KUM 32 binds to the alpha 2 adrenergic receptor of human platelets[1].
References
[1] Ferry N, et al. Critical assessment of the platelet adenylate cyclase system as a potential model for testing alpha 2 adrenergic activity. Biochem Pharmacol. 1986 May 1;35(9):1511-6. DOI:10.1016/0006-2952(86)90117-6
