3616-04-4

Phosphatidylcholine is the main phospholipid component in eukaryotic biofilms. Phosphatidylcholine exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Phosphorylcholine exhibits a surprising range of immunomodulatory properties[1].

ChEBI: Phosphocholine is the phosphate of choline; and the parent compound of the phosphocholine family. It has a role as an epitope, a hapten, a human metabolite, a mouse metabolite and an allergen. It is a conjugate acid of a choline phosphate(1-).

Human Endogenous Metabolite; Microbial Metabolite

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[1] Harnett W, et al. Phosphorylcholine: friend or foe of the immune system? Immunol Today. 1999 Mar;20(3):125-9. DOI:10.1016/s0167-5699(98)01419-4
[2] Tu S, et al., Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine. Macromol Biosci. 2011 Oct 10;11(10):1416-25. DOI:10.1002/mabi.201100111
[3] Cansev M, et al., Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol. 2008 Jul 28;589(1-3):315-22. DOI:10.1016/j.ejphar.2008.05.017
[4] Caligiuri G, et al., Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 2007 Aug 7;50(6):540-6. DOI:10.1016/j.jacc.2006.11.054