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RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity[1].

[1] Pang X, et al. Design, Synthesis, and Insecticidal Evaluation of?N-Pyridylpyrazole Amide Derivatives Containing 4,5-Dihydroisoxazole Amide as Potential Ryanodine Receptor Activators. J Agric Food Chem. 2023 Sep 20;71(37):13688-13695. . DOI:10.1021/acs.jafc.3c03199