2816929-47-0

Name	INDEX NAME NOT YET ASSIGNED
CAS	2816929-47-0
Molecular Formula	C43H53N13O8
Molecular Weight	879.96
MOL File	2816929-47-0.mol

Synonyms

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Chemical Properties

density	1.40±0.1 g/cm3(Predicted)
form	Solid
pka	11.86±0.43(Predicted)
color	Off-white to light yellow

Hazard Information

Uses

STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization[1].

in vivo

STING agonist-17 (compound 4a) (Intravenous injection; 0.015 mg/kg, 1.5 mg/kg; every other day; a week) has an inhibitory effect on tumor growth in CT26 cells-derived colon carcinoma female BALB/c mice^[1]. The pharmacokinetic parameters of Compound 4a in vivo^[1].

Parameter	Compound 4a
T_1/2 (h)	10.54 ± 4.10
Vss (L/kg)	>17.74 ± 5.29
CL (L/h/kg)	2.12 ± 0.27
AUC_last (μg h/mL)	4.20 ± 0.26
AUC_∞ (μg h/mL)	>4.78 ± 0.59

Animal Model:	Female BALB/c mice aged 6 weeks^[1]
Dosage:	0.015 mg/kg, 1.5 mg/kg
Administration:	Intravenous injection; every other day; a week
Result:	Inhibited tumor growth in both doses and caused 57% inhibition at a concentration of 1.5 mg/kg on the 17th day without weight loss.

References

[1] Min Jae Jeon, et al. Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor. J Med Chem. 2022 Apr 14;65(7):5407-5432. DOI:10.1021/acs.jmedchem.1c01795

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