2815286-02-1

mTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].

mTOR: 0.49 nM (IC₅₀); HDAC1: 0.91 nM (IC₅₀); HDAC6: 86 nM (IC₅₀); HDAC8: 27 nM (IC₅₀)

[1] Mingming Zhang, et al. Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy. Bioorg Med Chem Lett. 2021 Oct 1;49:128286. DOI:10.1016/j.bmcl.2021.128286