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209783-80-2

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Identification

Name
Entinostat
CAS
209783-80-2
Synonyms
Nsc706995
MS 275-27
entinostat
Entinostat/MS-275
MS-275 (Entinostat)
Entinostat(NSC-706995)
entinostat(HDAC inhibitor)
MS-275,Entinostat,SNDX-275
Entinostat (MS-275,SNDX-275)
(Pyridin-3-yl)Methyl 4-(2-AMinophenylcarbaMoyl)benzylcarbaMate
[4-(2-Amino-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester
N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
Entinostat N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester Entinostat (MS-275, SNDX-275)
3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide
Molecular Formula
C21H20N4O3
MDL Number
MFCD03453552
MOL File
209783-80-2.mol
Molecular Weight
376.409

Chemical Properties

Description
Entinostat (SNDX-275, MS-275) belongs to benzamide class HDACi and inhibits HDAC1 and 2, 3 and 9 and has low effect against HDAC4, 6, 7 and 8 (Khan et al. 2007). Entinostat is in phase II clinical trial for treatment of Hodgkin's lymphoma and advanced breast cancer (in combination with aromatase inhibitors) and metastatic lung cancer (in combination with erlotinib).
mp 
159-160 ºC
density 
1.315
storage temp. 
−20°C

solubility 
DMSO: 38 mg/mL, soluble

form 
solid

Hazard Information

Chemical Properties
Yellow Solid
Usage
Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies.

Safety Data

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-62-48/25-25-61
Safety Statements 
26-36-45
WGK Germany 
3

HS Code 
29333990
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