Description
The roots of Sternona japonica contain this complex alkaloid which forms
colourless crystals from MeOH containing solvent of crystallization. The base is
dextrorotatory with [α]D + 147.8° and the ultraviolet spectrum shows a broad
absorption maximum at 305 m/J.. The picrolonate has been prepared as yellow
needles, m.p. 237°C. The structure given above is based upon X-ray crystallo_x0002_graphic analysis of the MeOH solvate and on the already established configuration
of Stemonine (q.v.).
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Stemona bulbs.
Uses
Protostemonine is an alkaloid which provided protective effects of protostemonine in LPS/GalN-induced acute liver failure.
Definition
ChEBI: Protostemonine is an alkaloid. It has a role as a metabolite.
Synthesis
Tragacanth crushed into coarse powder (8.5 kg), with 8 times the amount of volume fraction of 90% ethanol heating reflux extraction 3 times, each time 1 h, combined with the extract, filtered. The filtrate was recovered to thick extract under reduced pres
References
Kondo, Satomi.,J. Pharrn. Soc., Japan, 67, 182, 185, 188 (1947)
Structure:
Irie et al., Chern. Pharrn. Bull., 21, 451 (1973)
