2748469-56-7

JWH 081 N-(5-hydroxypentyl) metabolite-d5 (Item No. 14361) is intended for use as an internal standard for the quantification of JWH 081 N-(5-hydroxypentyl) metabolite (Item No. 9000768) by GC- or LC-MS. Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.1 Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 (Item No. 10009018) and JWH 018 (Item No. 10900), have been identified from in vitro liver microsomal metabolism and from urine, respectively.2,3,4 JWH 081 (Item No. 10579) is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 081 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 081 that would be detectable both in serum and in urine. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

[1] N. UCHIYAMA. Identification of a cannabimimetic indole as a designer drug in a herbal product[J]. Forensic Toxicology, 2009, 27 1: 61-66. DOI: 10.1007/s11419-009-0069-y
[2] QIANG ZHANG. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS[J]. Analytical and Bioanalytical Chemistry, 2006, 386 5: 1345-1355. DOI: 10.1007/s00216-006-0717-6
[3] TIM SOBOLEVSKY  Grigory R  Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003
[4] CINDY L. MORAN. Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine[J]. Analytical Chemistry, 2011, 83 11: 4228-4236. DOI: 10.1021/ac2005636