2748212-89-5

JWH 250 N-(5-hydroxypentyl) metabolite-d5 (Item No. 11474) is intended for use as an internal standard for the quantification of JWH 250 N-(5-hydroxypentyl) metabolite (Item No. 9000767) by GC- or LC-MS. Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.1 Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.2,3,4 JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.WARNING This product is not for human or veterinary use.

[1] N. UCHIYAMA. Identification of a cannabimimetic indole as a designer drug in a herbal product[J]. Forensic Toxicology, 2009, 27 1: 61-66. DOI: 10.1007/s11419-009-0069-y
[2] QIANG ZHANG. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS[J]. Analytical and Bioanalytical Chemistry, 2006, 386 5: 1345-1355. DOI: 10.1007/s00216-006-0717-6
[3] TIM SOBOLEVSKY  Grigory R  Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003
[4] CINDY L. MORAN. Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine[J]. Analytical Chemistry, 2011, 83 11: 4228-4236. DOI: 10.1021/ac2005636