2748469-33-0

JWH 398 N-(5-hydroxypentyl) metabolite-d5 is intended for use as an internal standard for the quantification of JWH 398 N-(5-hydroxypentyl) metabolite by GC- or LC-MS. JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).1 It has been reported to be an adulterant of herbal products.2,3 JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.4 This product is intended for forensic and research applications.WARNING This product is not for human or veterinary use.

[1] HUFFMAN J. Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions[C]. 1900: 0. DOI: 10.1007/978-1-59745-503-9_3
[2] RURI KIKURA-HANAJIRI  Yukihiro G  Nahoko Uchiyama. Survey of current trends in the abuse of psychotropic substances and plants in Japan[J]. Legal Medicine, 2011, 13 3: Pages 109-115. DOI: 10.1016/j.legalmed.2011.02.003
[3] SEBASTIAN DRESEN. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds[J]. Journal of Mass Spectrometry, 2010, 45 10: 1186-1194. DOI: 10.1002/jms.1811
[4] TIM SOBOLEVSKY  Grigory R  Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003