2747914-17-4

(±)-JWH 398 N-(4-hydroxypentyl) metabolite-d5 (Item No. 14370) is intended for use as an internal standard for the quantification of JWH 398 N-(4-hydroxypentyl) metabolite (Item No. 10943) by GC- or LC-MS. JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).1 It has been reported to be an adulterant of herbal products.2,3 (±)-JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.4,5 This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

[1] HUFFMAN J. Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions[C]. 1900: 0. DOI: 10.1007/978-1-59745-503-9_3
[2] RURI KIKURA-HANAJIRI  Yukihiro G  Nahoko Uchiyama. Survey of current trends in the abuse of psychotropic substances and plants in Japan[J]. Legal Medicine, 2011, 13 3: Pages 109-115. DOI: 10.1016/j.legalmed.2011.02.003
[3] SEBASTIAN DRESEN. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds[J]. Journal of Mass Spectrometry, 2010, 45 10: 1186-1194. DOI: 10.1002/jms.1811
[4] LISA K BRENTS. Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.[J]. PLoS ONE, 2011: e21917. DOI: 10.1371/journal.pone.0021917
[5] LISA K. BRENTS . Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity[J]. Biochemical pharmacology, 2012, 83 7: Pages 952-961. DOI: 10.1016/j.bcp.2012.01.004