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L-Carnosine-d₄ is intended for use as an internal standard for the quantification of L-carnosine by GC- or LC-MS. L-Carnosine is an antioxidant.^1,2 It scavenges singlet oxygen in vitro when used at concentrations ranging from 1.5 to 15 mM.¹ In vivo, L-carnosine decreases plasma malondialdehyde (MDA) levels and lipid peroxidation and increases serum levels of nitric oxide (NO) in nephrectomized rats.²

L-Carnosine-d4 is the deuterium labeled L-Carnosine. L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

1. Hartman, P.E., Hartman, Z., and Ault, K.T. Scavenging of singlet molecular oxygen by imidazole compounds: High and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid Photochem. Photobiol. 51(1),59-66(1990).
2. Yapislar, H., and Taskin, E. L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats Med. Sci. Monit. 20,399-405(2014).