305-84-0

Name	L-Carnosine
CAS	305-84-0
EINECS(EC#)	206-169-9
Molecular Formula	C9H14N4O3
MDL Number	MFCD00005207
Molecular Weight	226.23
MOL File	305-84-0.mol

Chemical Properties

Appearance	Crystalline
Melting point	253 °C (dec.) (lit.)
alpha	20.9 º (c=1.5, H2O)
Boiling point	367.84°C (rough estimate)
density	1.2673 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	21 ° (C=2, H2O)
storage temp.	2-8°C
solubility	DMSO (Very Slightly), Water (Slightly)
form	crystalline
pka	2.62(at 25℃)
color	White
Stability:	Stable, but may be heat sensitive-store cold. Incompatible with strong oxidizing agents.
Water Solubility	almost transparency
Merck	1850
BRN	87671
InChIKey	CQOVPNPJLQNMDC-ZETCQYMHSA-N
Uses	carnosine is an anti-oxidant that works to prevent cellular damage because of free radical activity. Studies indicate an ability to boost the immunological functions. Carnosine is a naturally occurring amino acid. In cosmetics, it has anti-aging and skin-conditioning applications. less more
CAS DataBase Reference	305-84-0(CAS DataBase Reference)
EPA Substance Registry System	305-84-0(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
WGK Germany	2
RTECS	MS3080000
F	3-10
TSCA	Yes
HS Code	29332900
Safety Profile	Mildly toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. less more
Toxicity	LD50 oral in mouse: > 14930mg/kg less more

Hazard Information

Chemical Properties

Crystalline

Definition

ChEBI: A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.

benefits

L-Carnosine is a strong anti-glycosylation, free radical scavenging,anti-oxidant,anti-aging, anti-pollution.Brightenand repairthe skin. white powder.Its recommended dosage is 0.05~2%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 392, 1983 DOI: 10.1021/jo00151a026

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.

Purification Methods

Likely impurities are histidine and β-alanine. Crystallise L-carnosine from water by adding EtOH in excess. Recrystallise it from aqueous EtOH by slow addition of EtOH to a strong aqueous solution of the dipeptide. Its solubility in H2O is 33.3% at 25o. [Vinick & Jung J Org Chem 48 392 1983, Turner J Am Chem Soc 75 2388 1953, Sifford & du Vigneaud J Biol Chem 108 753 1935, Beilstein 25 H 516, 25 I 717, 25 II 408.]

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

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305-84-0

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Definition

benefits

Synthesis Reference(s)

Flammability and Explosibility

Biochem/physiol Actions

Purification Methods

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

Reference

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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