2707441-97-0

Aflatoxin M1-13C17 (AFM1-13C17) is intended for use as an internal standard for the quantification of AFM1 (Item No. 11297) by GC- or LC-MS. AFM1 is an active metabolite of aflatoxin B1 (Item No. 11293).1 It induces hepatocyte hyperplasia and hepatocellular carcinoma tumor formation in rats when administered at a dose of 1 mg/animal. AFM1 (6 mg/kg) increases hepatic total lipid levels and inhibits hepatic mitochondrial and cytoplasmic protein synthesis in rats.2WARNING This product is not for human or veterinary use.

[1] G.N. WOGAN  S. P. Carcinogenicity of synthetic aflatoxin M1 in rats[J]. Food and cosmetics toxicology, 1974, 12 3: Pages 381-384. DOI: 10.1016/0015-6264(74)90012-1
[2] M. RAMACHANDRA PAI  T. A V  N Jayanthi Bai. Aflatoxin induced inhibition of protein synthesis[J]. Toxicon, 1978, 16 3: Pages 283-287. DOI: 10.1016/0041-0101(78)90089-2