2700035-54-5

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].

HSP90: 0.83 μM (IC₅₀, fungal Hsp90); HDAC: 0.91 μM (IC₅₀, fungal HDACs); human HDAC: 3.0 μM (IC₅₀, human HDACs); HSP90: 19.52 μM (IC₅₀, human Hsp90)

[1] Li C, Tu J, Han G, Liu N, Sheng C. Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. Eur J Med Chem. 2022 Jan 5;227:113961. DOI:10.1016/j.ejmech.2021.113961