26057-70-5

Name	Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (+-)-
CAS	26057-70-5
Molecular Formula	C15H22O4
Molecular Weight	266.33
MOL File	26057-70-5.mol

Synonyms

Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (+-)- Furo[3,4-b]furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl-, (3aR,4R,6aR)-rel-

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Chemical Properties

Melting point	55-56 °C
Boiling point	458.2±45.0 °C(Predicted)
density	1.10±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	A residue

Hazard Information

Description

Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (K_i = 8 μM).

Uses

Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].

References

[1] Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4(12):2745-2754. DOI:10.1002/cbdv.200790223
[2] McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116(4):37P-38P. PMID:5435480

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