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Epicoccamide is a marine fungal metabolite originally isolated from E. purpurascens. It is comprised of three subunits including a glycosidic subunit, a fatty acid, and a tetramic acid. Epicoccamide has no activity against various bacteria, fungi, and nematodes and is not cytotoxic.

Epicoccamide is an ornate linear fatty acid with an acyl tetronic acid terminus and glycosidic alkyl terminus. Secondary metabolites of Epicoccum nigrum showed cytotoxic, anticancer, antimicrobial and anti-diabetic activities indicating Epicoccum nigrum is emerging source of unique bioactive metabolites. It is useful in biological studies.

Microbial Metabolite

[1] ANTHONY D. WRIGHT  Gabriele M K  Claudia Osterhage. Epicoccamide, a Novel Secondary Metabolite from a Jellyfish-Derived Culture of Epicoccum purpurascens.[J]. ChemInform, 2003, 34 26. DOI: 10.1002/chin.200326229
[2] HILAIRE V. KEMAMI WANGUN  Christian H  Hans Martin Dahse. Epicoccamides B–D, Glycosylated Tetramic Acid Derivatives from an Epicoccum sp. Associated with the Tree Fungus Pholiota squarrosa[J]. Journal of Natural Products , 2007, 70 11: 1800-1803. DOI: 10.1021/np070245q