2597958-02-4

Glucosylceramide synthase-IN-2 (compound T-690; po; 30, 100, 300 mg/kg)?reduces GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner in C57BL/6J mice^[1].
Glucosylceramide synthase-IN-2 (po; 5 mg/kg) has a C_max of 416 ng/mL. Glucosylceramide synthase-IN-2 shows good oral exposure (BA = 31%)^[1].
Glucosylceramide synthase-IN-2 reveals good brain exposure (Cu,brain = 0.21 μM at 30 mg/kg dosing, 1 h)^[1].