441061-33-2

Name	OGT2378
CAS	441061-33-2
Molecular Formula	C11H23NO4
MDL Number	MFCD07772309
Molecular Weight	233.3
MOL File	441061-33-2.mol

Synonyms

OGT2378 ACT-519276 Sinbaglustat 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-pentyl-, (2S,3R,4R,5S)-

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Chemical Properties

Boiling point	405.5±45.0 °C(Predicted)
density	1.201±0.06 g/cm3(Predicted)
form	Solid
pka	13.71±0.70(Predicted)
color	Light yellow to yellow

Hazard Information

Uses

Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions[1][2].

in vivo

Sinbaglustat (OGT2378; administered p.o., in the powdered chow, at a dose of 2500 mg/kg/day, corresponding to 35-40 mg of Sinbaglustat per mouse per day) is highly effective in impeding melanoma tumor growth?in vivo. The effectiveness of p.o. Sinbaglustat in this murine model suggests that inhibition of glycosphingolipid synthesis is a promising approach to inhibit tumor progression^[1].

Animal Model:	Female syngeneic C57BL/6 mice, 6-8 weeks old bearing MEB4 melanoma tumor^[1]
Dosage:	35-40 mg per mouse per day
Administration:	Administered p.o., in the powdered chow, at a dose of 2500 mg/kg/day
Result:	Inhibited MEB4 melanoma tumor growth in a syngeneic, orthotopic murine model.

References

[1] Michael Weiss,?et al. Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res.?2003 Jul 1;63(13):3654-8. PMID:12839955
[2] Martine Gehin,?et al. Assessment of Target Engagement in a First-in-Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders. Clin Transl Sci.?2021 Mar;14(2):558-567. DOI:10.1111/cts.12911

Spectrum Detail

OGT2378(441061-33-2)¹HNMR

Supplier

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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