252188-71-9

Ceftobiprole medocaril (s.c.; 3 × q12h; total daily doses of BAL9141 equivalents, 2.1, 4.2, or 8.4 mg/kg) causes ten-day cumulative survival rates ranged from 57 to 100% for female Swiss albino mice (body weight, 20 to 22 g) infected Pen^r Cro^s Ctx^s strain P-15986^[1].
Ceftobiprole medocaril (10, 40, 160 mg/kg; single dose; sc) has T_1/2s from 20 min to 31 min, as the dose rose from 40 mg/kg to 160 mg/kg. The AUC/dose values for the escalating single doses ranges from 0.585 to 1.33, and the C_max/dose values decreases from 1.08 to 0.90 in neutropenic thigh-infected mice^[2].