2511248-11-4

DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1]. DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1].

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[1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1.