2508-72-7

White or almost white crystalline powder

Antistine HCl,Ciba,US,1948

Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.

Antihistaminic;H1 antagonist

Imidazoline binding site ligand and an antihistamine

15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.

Antihistaminic

Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.

Store at -20°C