2443816-45-1

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

ULK-101 inhibited the induction of autophagy and autophagic flux under different stimuli. ULK-101 sensitizes KRAS-mutated lung cancer cells to nutrient stress.

Target	Value
ULK1 (Cell-free assay)	8.3 nM
ULK2 (Cell-free assay)	30 nM

ULK1: 1.6 nM (IC₅₀); ULK2: 30 nM (IC₅₀)

[1] Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84. DOI:10.1016/j.isci.2018.09.012