24356-94-3

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• Synthesis

  Using dienolone acetate (Ⅰ) as a raw material and acetone as a solvent, potassium permanganate was added at room temperature under formic acid catalysis for oxidation reaction. After the reaction was completed, the mixture was filtered and concentrated under reduced pressure to obtain compound (Ⅱ). Compound (Ⅱ) was condensed with acetophenone at room temperature in the presence of perchloric acid. After the reaction was completed, the mixture was concentrated under pressure to obtain compound (Ⅲ). Compound (Ⅲ) was hydrolyzed with potassium hydroxide methanol solution at room temperature and concentrated under reduced pressure to obtain 3-acetyl group to yield 3-hydroxyl group (Ⅳ). Compound (Ⅳ) was oxidized with chromium trioxide in methanol solvent, refluxed with toluene for 1 h, and purified by cooling crystallization to obtain the target compound phenylprogesterone (Ⅴ).

  

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