23932-84-5

138786-65-9

23932-84-5

General procedure for the synthesis of 6-fluoro-1(3H)-isobenzofuranone from methyl 2-(bromomethyl)-5-fluorobenzoate: 1. to a solvent mixture of 1,4-dioxane (30 mL) and water (30.0 mL) was added methyl 2-(bromomethyl)-5-fluorobenzoate (0.750 g, 3.04 mmol) and calcium carbonate (1.823 g, 18.21 mmol) and the mixture was heated and refluxed for 2.5 hours. 2. After completion of the reaction, the insoluble material was removed by filtration. 3. The filtrate was concentrated under vacuum and subsequently extracted with dichloromethane (4 x 30 mL). 4. The organic extracts were combined and dried with anhydrous magnesium sulfate. 5. The solvent was removed under vacuum to afford 6-fluoro-1(3H)-isobenzofuranone (0.423 g, 2.78 mmol, 92% yield) as a white solid.