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TCO-PEG8-TFP ester is a monodisperse crosslinker containing a TCO moiety and an PFP ester. The hydrophilic PEG8 arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label amine-containing antibodies, proteins and other macromolecules with TCO moiety. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters.

TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005