ChemicalBook CAS DataBase List 2304549-73-1

2304549-73-1

Name	GFB-8438
CAS	2304549-73-1
Molecular Formula	C16H14ClF3N4O2
MDL Number	MFCD32671553
Molecular Weight	386.76
MOL File	2304549-73-1.mol

Chemical Properties

density	1.52±0.1 g/cm3(Predicted)
solubility	DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Slightly soluble: 0.1-1 mg/ml
form	Solid
pka	9.09±0.60(Predicted)
color	Off-white to light yellow

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Hazard Information

Spectrum Detail

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Animal Model:	Sprague Dawley rats (DOCA-salt rat model of FSGS)^[1]
Dosage:	30 mg/kg
Administration:	s.c.; daily for 3 weeks
Result:	Significant reduction in urine protein concentrations.

Animal Model:	6-8 weeks old male SD rats^[1]
Dosage:	1 mg/kg
Administration:	i.v. (Pharmacokinetic?Analysis)
Result:	The?C_l,?V_ss,??and t_1/2?were?31?mL/min/kg,?1.17?L/kg,?and?0.5 hours, respectively.

2304549-73-1

Chemical Properties

Safety Data

Hazard Information

Uses

in vivo

IC 50

References

Spectrum Detail

Supplier

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