22884-10-2

83468-75-1

22884-10-2

The general procedure for the synthesis of (1-imidazolyl)acetic acid from the compound (CAS: 83468-75-1) was as follows: first, water (15.1 kg) was added to the reactor, followed by removal of chloroform by distillation, controlling the jacket temperature at 60-65 °C (boiling point of the azeotrope is 53 °C) and returning the aqueous phase back to the reactor by using a Dean-Stark water separator. After the chloroform is completely removed, the reactor jacket temperature is slowly raised to 115°C, at which point the tert-butanol and water form an azeotrope (boiling point of 80°C) that is distilled out. After the alcohol was completely removed, the remaining aqueous solution was cooled to room temperature and then drained from the reactor, resulting in 17.54 kg of solution containing (1-imidazolyl)acetic acid. The actual amount of (1-imidazolyl)acetic acid in the solution was determined by NMR to be 3.77 kg (29.9 mol) in 82.2% yield.