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Appearance: biotin is a white crystalline substance. Stability: it is fairly stable to air, heat, and light in dry form. In solution, however, it tends to degrade under strongly acidic or basic conditions. In the eight possible stereoisomers of biotin, only the (+)-isomer (called d-biotin) has biological activity. Biotin is covalently bound to its enzymes by an amide bond to the ε-amino group of a lysine residue and C-2 of the thiophane nucleus. The biotin molecule is activated by polarization of the O and N-1’atoms of the ureido nucleus. This leads to increased nucleophilicity at N-1′, which promotes the formation of a covalent bond between the electrophilic car bonyl phosphate formed from bicarbonate and ATP, and allows biotin to serve as a transport agent for CO2.

ChEBI:Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. It has a role as a prosthetic group, a coenzyme, a nutraceutical, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a cofactor and a fundamental metabolite. It is a member of biotins and a vitamin B7. It is a conjugate acid of a biotinate.

Bioepiderm (Sterling Winthrop).