2272917-12-9

Name	NDT-19795
CAS	2272917-12-9
Molecular Weight	367.4
MOL File	2272917-12-9.mol

Synonyms

NDT-19795 2-Pyrimidinepropanoic acid, α-[[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]oxy]-, (αR)-

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Chemical Properties

Boiling point	528.1±50.0 °C(predicted)
density	1.401±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
form	Solid
pka	2.37±0.10(predicted)
color	White to off-white

Hazard Information

Uses

NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the study of neurological diseases[1].

in vivo

NDT-19795 (3 mg/kg; i.v.; single dose) exhibits a brain-to-blood ratio of 0.07 in C57BL/6 mice, indicating low permeability through the blood-brain barrier^[1].

References

[1] Harrison D, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023;66(21):14897-14911. DOI:10.1021/acs.jmedchem.3c01398

Supplier

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Telephone 15317229551

Websitehttps://www.ureiko.com

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Beijing Famous Pharmaceutical Technology Co., Ltd

Telephone 15811073878

Websitehttp://www.peking-pharmacy.com

Zhejiang Huida Biotech Co., Ltd.

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

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