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Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α_2c adrenergic receptor (K_i = 4,060 nM in hα_2c preparations). Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically. It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).

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Quercetin 3-O-β-D-Glucuronide is the major metabolite of Quercetin (Q509500).

ChEBI: Miquelianin is a quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities. It has a role as a metabolite, an antioxidant and an antidepressant. It is a beta-D-glucosiduronic acid and a quercetin O-glycoside.

Overnight cultures of E. coli containing specific genes were inoculated into 50 mL of fresh LB medium containing appropriate antibiotics. Isopropyl β-D-1-thiogalactopyranoside (IPTG) was added to the mixture to a final concentration of 1 mM. the transform

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