ChemicalBook CAS DataBase List 2247950-73-6

2247950-73-6

Name	Pyrazolo[1,5-a]pyrimidin-7-amine, 5-(5-fluoro-3-pyridinyl)-N-[2-(1H-indol-3-yl)ethyl]-3-methyl-
CAS	2247950-73-6
Molecular Formula	C22H19FN6
Molecular Weight	386.42
MOL File	2247950-73-6.mol

Chemical Properties

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Animal Model:	6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)^[1]
Dosage:	10 mg/kg
Administration:	P.o.; daily for 12 days
Result:	Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.