22350-90-9

Dactylarin is cytotoxic antibiotic. Dactylarin isolated from Dactylaria lutea (Deuteromycetes). Cytotoxic effect of dactylarin on Ehrlich ascites carcinoma cells is caused by the inhibition of some SH-dependent glycolytic enzymes, especially of hexokinase (EC 2.7.1.1), glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) and 6-phosphofructokinase (EC 2.7.1.11). Dactylarin interacts with thiols, which explains its inhibitory effectiveness on the above glycolytic enzymes.

Altersolanol B (Dactylarin), a compound isolated from fungi, is structurally related to antibiotics and has been shown to induce ATP catabolism in Ehrlich ascites tumor cells.

[1] Adenosine triphosphate catabolism in Ehrlich ascites tumor cells treated with dactylarin
[2] Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin