Description
TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1?Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2?Inhibits MPTP opening and protects neurons from apoptosis.3?Induces oligodendrocyte maturation in culture and promotes myelin regeneration?in vivo?in a rodent model.4
Uses
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Uses
TRO 19622 interacts with mitochondria proteins and is able to promote neuron survival under stress conditions. It is a potential drug for treating amyotrophic lateral sclerosis (ALS). TRO 19622 is a neuroregenerative and neuroprotective agent. This is a research product for neuroscience.
Biological Activity
Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo . Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.
Biochem/physiol Actions
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
storage
Desiccate at +4°C
References
1) Bordet?et al.?(2007),?Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther.,?322?709
2) Ma?et al.?(2014),?NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol.,?75?209
3) Martin?et al.?(2011),?The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci.,?31?359
4) Magalon?et al. (2016),?Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology,?111?293
