219783-00-3

(±)-Longamide is a polycyclic bioactive metabolite isolated from sponges that has several bromopyrrole fragments, as well as a weak inhibitor of IDO1[1].

[1] Shiokawa Z, et al. Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase?1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide?B. ChemMedChem. 2016 Dec 16;11(24):2682-2689. DOI:10.1002/cmdc.201600446
[2] S. Marchais, et al. Synthesis of the marine carbinolamine (+/?) longamide control of N-1 and C-3 bromopyrrole nucleophilicity. Tetrahedron Letters. Volume 40, Issue 30, 23 July 1999, Pages 5519-5522.