ChemicalBook CAS DataBase List 2192-20-3

2192-20-3

Name	Hydroxyzine dihydrochloride
CAS	2192-20-3
EINECS(EC#)	218-586-3
Molecular Formula	C21H29Cl3N2O2
MDL Number	MFCD00058200
Molecular Weight	447.83
MOL File	2192-20-3.mol

Synonyms

2-[2-[4-[(4-chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride HYDROXYZINE DIHYDROCHLORIDE HYDROXYZINE HYDROCHLORIDE 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-ethanodihydroc 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanoldihydrochl 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanodihydro alamon ataraxdihydrochloride ataraxoiddihydrochloride ateraxdihydrochloride dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine neurolax orgatrax tran-qdihydrochloride tranquizinedihydrochloride vistarilsteraject 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride Durrax Quies Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride

Chemical Properties

Appearance	White Solid
Melting point	190-192°C
Fp	9℃
storage temp.	2-8°C
solubility	H₂O: soluble
form	powder
color	White to Off-White
Water Solubility	H2O: soluble alcohol: soluble chloroform: soluble
Usage	H1 receptor antagonist. Anxiolytic. Antihistaminic.
InChI	1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
InChIKey	ANOMHKZSQFYSBR-UHFFFAOYSA-N
SMILES	Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
CAS DataBase Reference	2192-20-3(CAS DataBase Reference)
EPA Substance Registry System	2192-20-3(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	KK2280000
TSCA	TSCA listed
REACH Registrations	Active
HS Code	29335990
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Repr. 2 STOT SE 3
Toxicity	LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal) less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Solid

Originator

Atarax,UCB,France,1956

Uses

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Uses

Anti histamines

Uses

Antihistaminic;H1 antogonist

Uses

H1 receptor antagonist. Anxiolytic. Antihistaminic.

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

Brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

General Description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

storage

4°C, protect from light

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Sinopharm Chemical Reagent Co,Ltd.

Telephone86-21-63210123

Websitehttp://www.reagent.com.cn

Maya High Purity Chemicals

Telephone+86 (573) 82222445 (0)18006601000 452520369

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm

ZhengZhou HuaWen Chemical Co.Ltd

Telephone0370-2785118 17550508557

Websitehttp://www.hnhwchem.com

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Wuhan Fortuna Chemical Co., Ltd

Telephone027-59207852 13308628970

Websitehttp://www.fortunachem.cn

ShangHai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttp://www.shyuanye.com

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Telephone025-66113011 13913916777

Websitehttp://www.aikonchem.com/

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

UHN Shanghai Research & Development Co., Ltd.

Telephone021-58958002 18930822973

Websitehttp://www.uhnshanghai.com

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810 18652991625

Website

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

1of4

Related Products

Send Inquriy