2183440-37-9

TCO-PEG4-maleimide is a bifunctional crosslinker containing a TCO moiety and a maleimide group. The maleimide group can react with thiol groups to form a stable thioester bond between pH 6.5 to 7.5. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. TCO can be used to label antibodies, proteins and othe rtetrazine-containing macromolecules.

TCO-PEG9-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005