RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.
Uses
RPR203494 is a potent inhibitor against CYP isozymes. RPR203494 shows inhibition against p38 kinase with an IC50 value of 9 nM and an EC50 value of 60 nM. RPR203494 demonstrates an inhibition of hepatic Cytochrome P450. RPR203494 is promising for research of rheumatoid arthritis (RA)[1].
References
[1] Collis AJ, et al. RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Bioorg Med Chem Lett. 2001 Mar 12;11(5):693-6. DOI:10.1016/s0960-894x(01)00034-8
