49763-96-4

White Solid

An antiepileptic drug

An epilepsy drug. It has been used as co-therapy for treatment of epilepsy

Stiripentol is a third-generation antiepileptic compound. It is a positive allosteric modulator of GABA_A receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α₃ subunits and to a lower extent in those containing β₁ or ε subunits. It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices. Stiripentol (500 μM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5. Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.

ChEBI: 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol is a phenylpropanoid.

Anti-convulsant drug

A method for the preparation of Stiripentol comprising the steps of:

(1) 120g of piperonal was put into a mixed solvent of 0.2L of ethanol and 2.4L of distilled water, 160g of solid NaOH, 2.6g of benzyltributylammonium chloride and 120g of meth

Store at -20°C

[1] ?USZCZKI J J. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions[J]. Pharmacological Reports, 2009, 61 2: Pages 197-216. DOI: 10.1016/s1734-1140(09)70024-6
[2] FISHER J L. The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator[J]. Neuropharmacology, 2009, 56 1: Pages 190-197. DOI: 10.1016/j.neuropharm.2008.06.004
[3] PASCALE P. QUILICHINI. Stiripentol, a Putative Antiepileptic Drug, Enhances the Duration of Opening of GABAA-Receptor Channels[J]. Epilepsia, 2006, 47 4: 704-716. DOI: 10.1111/j.1528-1167.2006.00497.x
[4] NAGISA SADA. Targeting LDH enzymes with a stiripentol analog to treat epilepsy[J]. Science, 2015, 347 6228. DOI: 10.1126/science.aaa1299