21416-88-6

Name	HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
CAS	21416-88-6
Molecular Formula	C12H18N4O4
MDL Number	MFCD01702964
Molecular Weight	282.3
MOL File	21416-88-6.mol

Synonyms

Brn 3981691 meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane ICRF-193 apoptosis inducer, arabinosidase substrate 2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso- 2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel- 2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)- 2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel-

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Chemical Properties

density	1.308
storage temp.	-20°C
solubility	DMSO: soluble4mg/mL
form	Solid
color	White to off-white

Safety Data

Hazard Codes	Xn
Risk Statements	22-43 less more
Safety Statements	36/37 less more
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	TL6380200

Hazard Information

Uses

ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.

Definition

ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent.

General Description

ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable?complex.

Biochem/physiol Actions

ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks.

Supplier

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Shanghai Maclean Biochemical Technology Co., LTD

Telephone021-50706066 15221275939

Websitehttp://www.macklin.cn/

Shanghai Tachizaki Biomedical Research Center

Telephone 18014399201

Websitehttp://www.chemlab-tachizaki.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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