213971-34-7

FX-11 is an inhibitor of lactate dehydrogenase-A (LDH-A; Ki = 8 μM). It is selective for LDH-A over GAPDH (Ki = >300 μM). FX-11 increases oxygen consumption and the production of reactive oxygen species (ROS), as well as induces cell death in P493-6 lymphoblastoid cells. In vivo, FX-11 (42 μg/animal, i.p.) reduces tumor volume in a P493-6 mouse xenograft model. It also reduces tumor weight in a BxPC-3 mouse xenograft model when administered at a dose of 2 mg/kg.

This compound is used in the synthesis of novel lactate dehydrogenase A inhibitors.

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[1] ANNE LE. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 2037-2042. DOI: 10.1073/pnas.0914433107
[2] G. MOHAMMAD. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer[J]. Cancers, 2019. DOI: 10.3390/cancers11091372